NanoSizer MINI is the world’s first fully assembled lipid, liposome, and liquid polymer and nanoparticle extruder allowing researchers to save time and money, and avoid any chance of batch to batch contaminations which could save valuable laboratory and pharmaceutical solutions. Faster, cleaner, and easier extrusion and sizing every single time. NanoSizer MINI not only allows for performing research with highest level of confidence of cleanliness, it will also save tremendous amount of time and money to maximize the efficiency of the work. No assembly, cleaning or contamination.

NanoSizer MINI and PLUS Sterile are the world’s first disposable sterilized and fully assembled lipid/liposome extruder for sizing liposome, and liquid polymer and nanoparticle allowing researchers to save time and money, and avoid any chance of batch to batch contamination and growing bacteria which can save you precious laboratory and pharmaceutical solutions. Faster, cleaner, and easier extrusion every single time. Great for cell-included sizing research and sterilized liposome production. No need for autoclaving. Ethylene Oxide (EtO) sterilization process is perfoemed for sterilizing the extruder.

NanoSizer AUTO is transforming fully sterile liposome production of small and large volumes of solution alike, simplifying scale-up from the research labs to pharmaceutical manufacturing. This technology allows to extrude liposomes by pressing a button whether is 1 mL or 300 L with no need of assembling or cleaning. The fact that the temperature, flow rate, pressure, and number of passes are completely controlled makes the results consistent and repeatable which is a great factor in research, development and production of these nanoparticles.

Gene Delivery: messenger RNA (mRNA), Small interfering RNA (siRNA), DNA ProFECT Technology

Encapsulation and Fomulation

Liposome and Lipid Nanoparticle Design

Antibody Conjugated Liposomes

Analytical Method Development

Stability Testing

PEGylated Liposomes and Lipid Nanoparticles

Surface Modified and Labeled Liposomes 

Fluorescent Liposomes and Lipid Nanoparticles

Encapsulation of Hydrophilic and Hydrophobic Compounds

Nano Scale Water Soluble and Dispersible Hydrophobic Compounds: Cannabinoids (CBD), Cholesterol, Vitamins, & Essential oils

pH-Sensitive and Labeled Liposomes and Lipid Nanoparticles

Magnetic Liposomes and Lipid Nanoparticles

Transfection Agents for siRNA, RNA, , DNA, and Protein Delivery

Continuous Large Scale Manufacturing of Liposome and Lipid Nanoparticle Solutions

Sterile Small to Large Scale Batch Sizes

Thin Film Hydration Method

Extrusion Technique Using NanoSizer Technology

Sonication Process

Microfluidics Approach

Ethanol Injection System

Process Development, Verification and Validation

cGMP Product Development

Technology Transfer

Quality Control and Quality Assurance - Risk Management

Full Scale Product Launch 

Commercialization

Large Scale Production of Water Soluble and Dispersible Hydrophobic Compounds:

Cannabinoids CBD, Cholesterol, Vitamins, & Essential oils

Size Characterization: Dynamic Light Scattering

Surface Charge Density: Zeta Potential Measurements

Concentration and Composition Analysis

High Performance Liquid Chromatography

Gas Chromatography

Mass Spectroscopy 

Element Phosphorus: UV/Vis

Transition Behavior: Differential Scanning Calorimetry

Microscopy and Imaging Analysis

Electrophysiology 

Differential Scanning Calorimetry for Transition Behavior

Encapsulation Efficiency 

Stability, Shelf Life, and Aging Testing

Drug Delivery and Translational Medicine Efficacy