Lipid Nanoparticles and Messenger RNA (mRNA)

Lipid nanoparticles are nano-sized structures made of lipids. Lipids are the same building blocks of the cell wall. Therefore these nanoparticles are a great candidate to communicate with the cells. As a result, these nanoparticles are being extensively used in delivering Active Pharmaceutical Ingredients (API) and nucleic acids for therapeutics and vaccines.

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In recent years, the use of lipid nanoparticles in the pharmaceutical industry has been overgrowing. These nanoparticles can deliver the APIs more effectively, with significantly improved bioavailability and lower toxicity, showing the great promise of these technologies.

In 2020, these technologies' promise became most evident when the two leading vaccines for COVID 19 by Moderna Therapeutics and BioNTech/Pfizer used Nanoparticles to deliver Messenger RiboNucleic Acid (mRNA).

While these promising vaccines used lipid nanoparticle technologies, these delivery vehicles' applications are not limited to vaccines. They are several candidates now for drugs used in various types of cancers and other infectious diseases.

The goal of these lipid nanoparticles to deliver active ingredients most efficiently with the least toxicity to the target of interest (i.e., disease origin).

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