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Cationic and Ionizable Lipid Nanoparticles for Gene Therapy and Vaccine Applications

Cationic and Ionizable Lipid Nanoparticles for Gene Therapy and Vaccine Applications Author: Nima Tamaddoni, PhD 13th August 2021 Download PDF Cationic and Ionizable Lipid Nanoparticles for Gene Therapy and Vaccine Applications Nima Tamaddoni, Ph.D.T&T Scientific Corporation, Knoxville, TN 37918 USA New generations of lipid nanocarriers, including solid lipid nanoparticles, cationic lipid-nucleic acid complexes, and nanostructured lipid carriers, are physically more stable and complex than previous nanoparticles used. Delivery time can be controlled with these lipid nanoparticles (Guevara et al., 2020). COVID-19 vaccines development in a brief period would not have been possible if we had not spent decades researching nanoparticles. Lipid nanoparticles are being used to treat cancer before and now are the main component of mRNA vaccines for COVID-19....

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Lipid Nanoparticles and Liposomes: Delivering Clinical Breakthroughs

Liposomes have long been established as an effective drug delivery vehicle for API with poor pharmacokinetics, limited bioavailability or solubility, and high toxicity. Discovered in the 1960s by Alec D. Bangham, liposomes were originally utilized as an artificial bilayer to study membranes' biophysical properties. The liposome morphology can be described as an aqueous core surrounded by one or ma

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