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Anionic Liposomes and Lipid Nanoparticles

Anionic liposomes are structures that are made of negatively charged lipids and are vastly utilized in gene delivery and transfection applications.

DOPS:DOPC Liposomes (1-2)
DOPS Liposomes (3)

 

References:

1) Forssen, Eric A., and Z. A. Tökès. "Use of anionic liposomes for the reduction of chronic doxorubicin-induced cardiotoxicity." Proceedings of the National Academy of Sciences 78.3 (1981): 1873-1877.

2) Patil, Siddhesh D., David G. Rhodes, and Diane J. Burgess. "Anionic liposomal delivery system for DNA transfection." The AAPS journal 6.4 (2004): 13-22.

3)  Tarahovsky, Yury S., Rumiana Koynova, and Robert C. MacDonald. "DNA release from lipoplexes by anionic lipids: correlation with lipid mesomorphism, interfacial curvature, and membrane fusion." Biophysical journal 87.2 (2004): 1054-1064.