Due to the instability of liposomal dispersions, lyophilization is commonly applied to improve liposomal drug stability, and facilitate transportation, storage and improve product shelf-life.
Lyophilized DOTAP Liposomes (1,2)
|Lyophilized DOTAP-DOPC Liposomes (1,2)|
|Lyophilized DOTAP-Chol Liposomes (1,2)|
1) Chen, Chengjun, et al. "An overview of liposome lyophilization and its future potential." Journal of controlled release 142.3 (2010): 299-311.
2) Wang, Yuwei, and David W. Grainger. "Lyophilized liposome-based parenteral drug development: Reviewing complex product design strategies and current regulatory environments." Advanced drug delivery reviews 151 (2019): 56-71.