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Publications and Resources

DESIGNING NANOPARTICLE-BASED DRUG DELIVERY SYSTEMS FOR PRECISION MEDICINE

In this mini-review the authors focus on advances in several most commonly used nanoparticles, from their nature and design, to drug delivery system and clinical application, that they overcome heterogeneous barriers in precision medicine, thereby ultimately improve patient outcome overall.

YANG, JIANHUA, CHENGYOU JIA, AND JIANSHE YANG. "DESIGNING NANOPARTICLE-BASED DRUG DELIVERY SYSTEMS FOR PRECISION MEDICINE." INT J MED SCI 18.13 (2021): 2943-2949.

SYSTEMIC DELIVERY OF MRNA AND DNA TO THE LUNG USING POLYMER-LIPID NANOPARTICLES

Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles

KACZMAREK, JAMES C., ET AL. "SYSTEMIC DELIVERY OF MRNA AND DNA TO THE LUNG USING POLYMER-LIPID NANOPARTICLES." BIOMATERIALS (2021): 120966.

SELF-AMPLIFYING RNA SARS-COV-2 LIPID NANOPARTICLE VACCINE CANDIDATE INDUCES HIGH NEUTRALIZING ANTIBODY TITERS IN MICE

This study provide insight into the vaccine design and evaluation of immunogenicity to enable rapid translation to the clinic.

MCKAY, PAUL F., ET AL. "SELF-AMPLIFYING RNA SARS-COV-2 LIPID NANOPARTICLE VACCINE CANDIDATE INDUCES HIGH NEUTRALIZING ANTIBODY TITERS IN MICE." NATURE COMMUNICATIONS 11.1 (2020): 1-7. APA

SOLID LIPID NANOPARTICLES FOR ORAL DRUG DELIVERY

The aim of the article is to review the diverse instrumental techniques have been decorated and oral administration of SLNs is logistically reviewed.

Basha, S. Khaleel, et al. "Solid lipid nanoparticles for oral drug delivery." Materials Today: Proceedings 36 (2021): 313-324.

LIPID NANOPARTICLES AS DELIVERY SYSTEMS FOR RNA-BASED VACCINES

This review highlights key advances in the development of LNPs and reviews the application of mRNA-based vaccines formulated in LNPs for use against infectious diseases and cancer.

Aldosari, Basmah N., Iman M. Alfagih, and Alanood S. Almurshedi. "Lipid nanoparticles as delivery systems for RNA-based vaccines." Pharmaceutics 13.2 (2021): 206.

IONIZABLE LIPID NANOPARTICLES FOR IN UTERO MRNA DELIVERY

This article demonstrates that LNPs can deliver mRNAs to induce hepatic production of therapeutic secreted proteins. These LNPs may provide a platform for in utero mRNA delivery for protein replacement and gene editing.

Riley, Rachel S., et al. "Ionizable lipid nanoparticles for in utero mRNA delivery." Science Advances 7.3 (2021): eaba1028.APA

THE MRNA-LNP PLATFORM’S LIPID NANOPARTICLE COMPONENT USED IN PRECLINICAL VACCINE STUDIES IS HIGHLY INFLAMMATORY

The preclinical LNPs are similar to the ones used for human vaccines, which could also explain the observed side effects in humans using this platform.

Ndeupen, Sonia, et al. "The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory." bioRxiv (2021). APA

MRNA-LIPID NANOPARTICLE COVID-19 VACCINES: STRUCTURE AND STABILITY

To improve the stability of mRNA-LNP vaccines, optimization of the mRNA nucleotide composition should be prioritized. Secondly, a better understanding of the milieu the mRNA is exposed to in the core of LNPs may help to rationalize adjustments to the LNP structure to preserve mRNA integrity. Moreover, drying techniques, such as lyophilization, are promising options still to be explored.

Riley, Rachel S., et al. "Ionizable lipid nanoparticles for in utero mRNA delivery." Science Advances 7.3 (2021): eaba1028. APA

LIPID-BASED NANOCARRIERS AS DRUG DELIVERY SYSTEM AND ITS APPLICATIONS

This chapter provides a brief description of advantage, types of lipid nanocarriers, their preparation method, characteristic properties, and characterization/evaluation methods including instrumentations and application in the nano-pharmaceutical field.

Jain, Vikas, et al. "Lipid‐Based Nanocarriers as Drug Delivery System and Its Applications." Nanopharmaceutical Advanced Delivery Systems (2021): 1-29. APA

NANOPARTICLES AS ADJUVANTS AND NANODELIVERY SYSTEMS FOR MRNA-BASED VACCINES

The aim of this review is to discuss the recent developments and applications of biodegradable nano-delivery systems that improve RNA-based vaccine delivery and enhance the immunological response against targeted diseases

Alfagih, Iman M., et al. "Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines." Pharmaceutics 13.1 (2021): 45. APA

NEXT-GENERATION VACCINES: NANOPARTICLE-MEDIATED DNA AND MRNA DELIVERY

This review will summarize the many varieties of novel NP formulations for DNA and mRNA vaccine delivery as well as give the reader a brief synopsis of NP vaccine clinical trials. Finally, the future perspectives and challenges for NP-mediated nucleic acid vaccines will be explored.

Ho, William, et al. "Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery." Advanced Healthcare Materials 10.8 (2021): 2001812. APA

NANOMATERIAL DELIVERY SYSTEMS FOR MRNA VACCINES

This article is an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants of the performance of lipid nanoparticles in mRNA vaccines

Buschmann, Michael D., et al. "Nanomaterial delivery systems for mRNA vaccines." Vaccines 9.1 (2021): 65. APA