SKU Product Number: TT-008-0010

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Quantity

No Assembly Needed

No Cleaning Required

No Chance of Cross-Contamination

Consistent Results with a Repeatable Process

Quantity Price Break Unit Price

1+ Box

$89

5+ Box

$84.55

10+ Box

$80.10

20+ Box

$75.65

NanoSizerTM Extruders enable rapid extrusion of liposomes, polymerosomes, cell membranes, and colloidal suspensions. NanoSizerTM can be used in general nanoparticle sizing and filtration applications. Each extruder contains a single clean track-etched polycarbonate membrane. A range of pore-sizes is available: 50 nm, 100 nm, 200 nm, 400 nm, 800 nm, 1 µm, 2 µm, 5 µm, 1 µm. All other sizes may be available on request: contact us at Support@ttscientific.com. The advantages of NanoSizer extruders provides significant advantages for its users and it is compatible with Heat/Extrusion Block, our patent pending extrusion block allows firmly holding of extruder system in place.

No Assembly Needed

No Cleaning Required

No Chance of Cross-Contamination

Consistent Results with a Repeatable Process

NanoSizer MINI Instruction

How to make liposome/LNP Solutions

NanoSizer MINI Studies White Paper/Poster

NanoSizer MINI Instruction

White Collaborative Paper with Malvern

NanoSizer MINI Studies White Paper/Poster

T&T Scientific ProFECT Brochure Overview

1) What do I need to get started with extrusion?

Extrusion is easy with NanoSizer™ extruders. All you need is liposome solution, two syringes, and a NanoSizer™ MINI extruder. Heat blocks are also available for extrusion of high transition temperature lipids.

 

Each NanoSizer™ contains a Whatman (GE Healthcare) track-etched polycarbonate membrane.

3) What kind of syringes are suitable for extrusion with NanoSizer™?

NanoSizer™ extruders can be used with needle-tipped Hamilton glass syringes provided with other common liposome mini-extruders. For an improved experience, NanoSizer™ extruders accommodate single-use luer-lock syringes with a needle attachment: this means no cleaning of the syringe and no chance for leakage due to worn plunger assemblies. Both glass and single-use syringes are available at www.ttscientific.com.

4) What kind of needles are required for extrusion with NanoSizer™?

The needles provided with single-use syringes are 22 gauge, blunt (NOT sharp) needles, designed with an appropriate length for use with NanoSizer™ extruders.

5) Can NanoSizer™ be heated?

Yes, NanoSizer™ can be heated up to at least 100°C using our heating block designed for use with a hot plate.

6) Do I need a heat block?

Liposome solutions generally require heating to a temperature above the transition temperature of the lipid-mixture (i.e. 41°C for DPPC) before extrusion. When the temperature is too low, it may seem hard, or even impossible, to “push” or extrude the solution.

7) Is NanoSizer™ suitable for extrusion of high volume liposome solutions?

Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

8) Will I get the same size distribution that I get with other extruders?

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.

 

2) Do NanoSizer™ extruders include a polycarbonate membrane?

Each NanoSizer™ contains double Whatman (GE Healthcare) track-etched polycarbonate membrane.

3) What kind of syringes are suitable for extrusion with NanoSizer™?

NanoSizer™ extruders can be used with needle-tipped Hamilton glass syringes provided with other common liposome mini-extruders. For an improved experience, NanoSizer™ extruders accommodate single-use luer-lock syringes with a needle attachment: this means no cleaning of the syringe and no chance for leakage due to worn plunger assemblies. Both glass and single-use syringes are available at www.ttscientific.com.

4) What kind of needles are required for extrusion with NanoSizer™?

The needles provided with single-use syringes are 22 gauge, blunt (NOT sharp) needles, designed with an appropriate length for use with NanoSizer™ extruders.

5) Can NanoSizer™ be heated?

Yes, NanoSizer™ can be heated up to at least 100°C using our heating block designed for use with a hot plate.

6) Do I need a heat block?

Liposome solutions generally require heating to a temperature above the transition temperature of the lipid-mixture (i.e. 41°C for DPPC) before extrusion. When the temperature is too low, it may seem hard, or even impossible, to “push” or extrude the solution.

7) Is NanoSizer™ suitable for extrusion of high volume liposome solutions?

Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

8) Will I get the same size distribution that I get with other extruders?

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.

 

3) What kind of syringes are suitable for extrusion with NanoSizer™?

NanoSizer™ extruders can be used with needle-tipped Hamilton glass syringes provided with other common liposome mini-extruders. For an improved experience, NanoSizer™ extruders accommodate single-use luer-lock syringes with a needle attachment: this means no cleaning of the syringe and no chance for leakage due to worn plunger assemblies. Both glass and single-use syringes are available at www.ttscientific.com.

4) What kind of needles are required for extrusion with NanoSizer™?

The needles provided with single-use syringes are 22 gauge, blunt (NOT sharp) needles, designed with an appropriate length for use with NanoSizer™ extruders.

5) Can NanoSizer™ be heated?

Yes, NanoSizer™ can be heated up to at least 100°C using our heating block designed for use with a hot plate.

6) Do I need a heat block?

Liposome solutions generally require heating to a temperature above the transition temperature of the lipid-mixture (i.e. 41°C for DPPC) before extrusion. When the temperature is too low, it may seem hard, or even impossible, to “push” or extrude the solution.

7) Is NanoSizer™ suitable for extrusion of high volume liposome solutions?

Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

8) Will I get the same size distribution that I get with other extruders?

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.

 

4) What kind of needles are required for extrusion with NanoSizer™?

NanoSizer™ extruders can be used with needle-tipped Hamilton glass syringes provided with other common liposome mini-extruders. For an improved experience, NanoSizer™ extruders accommodate single-use luer-lock syringes with a needle attachment: this means no cleaning of the syringe and no chance for leakage due to worn plunger assemblies. Both glass and single-use syringes are available at www.ttscientific.com.

The needles provided with single-use syringes are 22 gauge, blunt (NOT sharp) needles, designed with an appropriate length for use with NanoSizer™ extruders.

5) Can NanoSizer™ be heated?

Yes, NanoSizer™ can be heated up to at least 100°C using our heating block designed for use with a hot plate.

6) Do I need a heat block?

Liposome solutions generally require heating to a temperature above the transition temperature of the lipid-mixture (i.e. 41°C for DPPC) before extrusion. When the temperature is too low, it may seem hard, or even impossible, to “push” or extrude the solution.

7) Is NanoSizer™ suitable for extrusion of high volume liposome solutions?

Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

8) Will I get the same size distribution that I get with other extruders?

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.

 

5) Can NanoSizer™ be heated? 

Yes, NanoSizer™ can be heated up to at least 100°C using our heating block designed for use with a hot plate.

 

Liposome solutions generally require heating to a temperature above the transition temperature of the lipid-mixture (i.e. 41°C for DPPC) before extrusion. When the temperature is too low, it may seem hard, or even impossible, to “push” or extrude the solution.

7) Is NanoSizer™ suitable for extrusion of high volume liposome solutions?

Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

8) Will I get the same size distribution that I get with other extruders?

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.

 

6) Do I need a heat block?

Yes, NanoSizer™ can be heated up to at least 100°C using our heating block designed for use with a hot plate.

Liposome solutions generally require heating to a temperature above the transition temperature of the lipid-mixture (i.e. 41°C for DPPC) before extrusion. When the temperature is too low, it may seem hard, or even impossible, to “push” or extrude the solution. Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

7) Is NanoSizer™ suitable for extrusion of high volume liposome solutions?

Automated extrusion systems are available for small, medium, and large volume production (milliliter to hundreds of liters, i.e. 300L+).

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.

 

8) Will I get the same size distribution that I get with other extruders?

Yes. Dynamic light scattering (DLS) measurements were used to compare the size distribution of liposomes created with NanoSizer™ and another common extruder. Results show equivalent, and possibly even narrower and improved size distribution via NanoSizer™ extrusion.