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P-lysoPC, LPC (16:0-0:0 PC): 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine
LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.
|Storage||-20°C or below|
Field of Use: LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.
Matsumoto, T., Kobayashi, T., Kamata, K. (2007) “Role of lysophosphatidylcholine (LPC) in atherosclerosis”, Curr. Med. Chem. 14, 3209-220.
Hazardous Properties and Cautions: No hazardous or toxic properties are known for this substance. 1-Palmitoyl-2- hydroxy-sn-glycero-3-phosphatidylcholine is not listed as a hazardous waste or as a Toxic Chemical subject to release reporting under the Emergency Planning and Community Right-to-Know Act. 1-Palmitoyl-2-hydroxy-sn-glycero-3- phosphatidylcholine is not listed on the Chemical Inventory of the Toxic Substance Control Act, and is manufactured and shipped only in small quantities, intended for research and development in a laboratory utilizing prudent procedures for handling chemicals of unknown toxicity, under the supervision of persons technically qualified to evaluate potential risks and authorized to enforce appropriate health and safety measures. As with all research chemicals, precautions should be taken to avoid unnecessary exposures or risks.
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